HCV(CMIA)

Pathogenesis ea hepatitis C e ntse e sa tsejoe hantle.Ha HCV e ikatisetsa liseleng tsa sebete, e baka liphetoho sebopeho le ts'ebetso ea lisele tsa sebete kapa e kena-kenana le motsoako oa liprotheine tsa lisele tsa sebete, tse ka bakang ho senyeha le necrosis ea lisele tsa sebete, e leng se bontšang hore HCV e senya sebete ka ho toba 'me e phetha karolo ea pathogenesis.Leha ho le joalo, litsebi tse ngata tsa lipalo li lumela hore cellular immunopathological reaction e ka phetha karolo ea bohlokoa.Ba fumane hore lefu la sebete la mofuta oa C, joalo ka hepatitis B, le na le lisele tse kenang haholo tsa CD3+ liseleng tsa eona.Lisele tsa Cytotoxic T (TC) li hlasela ka ho khetheha lisele tse lebisitsoeng tsa tšoaetso ea HCV, tse ka bakang tšenyo ea lisele tsa sebete.


Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Lintlha tsa motheo

Lebitso la Sehlahiswa Catalog Mofuta Moamoheli/Mohloli Tšebeliso Lisebelisoa Epitope COA
HCV Core-NS3-NS5 fusion antigen BMIHCV203 Antigen E.coli Tšoara CMIA,
WB
/ Khoasolla
HCV Core-NS3-NS5 fusion antigen BMIHCV204 Antigen E.coli Kopanya CMIA,
WB
/ Khoasolla
HCV Core-NS3-NS5 fusion antigen-Bio BMIHCVB02 Antigen E.coli Kopanya CMIA,
WB
/ Khoasolla
HCV Core-NS3-NS5 fusion antigen BMIHCV213 Antigen HEK293 sele Kopanya CMIA,
WB
/ Khoasolla

Pathogenesis ea hepatitis C e ntse e sa tsejoe hantle.Ha HCV e ikatisetsa liseleng tsa sebete, e baka liphetoho sebopeho le ts'ebetso ea lisele tsa sebete kapa e kena-kenana le motsoako oa liprotheine tsa lisele tsa sebete, tse ka bakang ho senyeha le necrosis ea lisele tsa sebete, e leng se bontšang hore HCV e senya sebete ka ho toba 'me e phetha karolo ea pathogenesis.Leha ho le joalo, litsebi tse ngata tsa lipalo li lumela hore cellular immunopathological reaction e ka phetha karolo ea bohlokoa.Ba fumane hore lefu la sebete la mofuta oa C, joalo ka hepatitis B, le na le lisele tse kenang haholo tsa CD3+ liseleng tsa eona.Lisele tsa Cytotoxic T (TC) li hlasela ka ho khetheha lisele tse lebisitsoeng tsa tšoaetso ea HCV, tse ka bakang tšenyo ea lisele tsa sebete.

RIA kapa ELISA

Radioimmunodiagnosis (RIA) kapa enzyme-linked immunosorbent assay (ELISA) e ne e sebelisetsoa ho lemoha anti HCV ka serum.Ka 1989, Kuo et al.e thehile mokhoa oa radioimmunoassay (RIA) bakeng sa anti-C-100.Hamorao, Ortho Company e atlehile ho hlahisa tlhahlobo ea immunosorbent e amanang le enzyme (ELISA) ho lemoha anti-C-100.Mekhoa ena ka bobeli e sebelisa recombinant tomoso e hlahisitsoeng ke kokoana-hloko antigen (C-100-3, protheine e kentsoeng ke NS4, e nang le 363 amino acid), ka mor'a ho hloekisa, e koahetsoe ka likoti tse nyenyane tsa polasetiki, ebe e kenngoa ka serum e lekiloeng.Joale kokoana-hloko ea antigen e kopantsoe le anti-C-100 serum e lekiloeng.Qetellong, isotope kapa enzyme e ngotsoeng mouse anti human lgG monoclonal antibody e eketsoa, ​​​​'me substrate e eketsoa bakeng sa ho khetholla mebala.


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